Depression Home > Drug Interactions With Paroxetine

Paroxetine and Serotonin Syndrome

Several of the known interactions with paroxetine are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.

Paroxetine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when paroxetine is combined with any of the drugs listed above.
Combining alcohol and paroxetine may cause unwanted side effects (see Alcohol and Paxil).
Taking paroxetine and aspirin together can increase your risk of stomach bleeding. Talk to your healthcare provider before taking aspirin and paroxetine together.
Atomoxetine (Strattera)
Paroxetine can increase the level of Strattera in your blood, increasing your risk of side effects. If you are taking paroxetine with Strattera, your healthcare provider may need to lower your Strattera dosage.
Buspirone (BuSpar)
Because combining paroxetine with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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