Depression Home > Drug Interactions With Paroxetine
Certain Arrhythmia Medications
Taking paroxetine with certain arrhythmia medications can increase the level of paroxetine or the arrhythmia medication in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor you more closely and may need to adjust your dose of these medications.
Certain Seizure Medications
Certain seizure medications (phenobarbital and phenytoin) may decrease the level of paroxetine in your blood, perhaps making it less effective. Also, taking these medications with paroxetine can lead to increased drowsiness. Your healthcare provider may need to adjust your dose of these medications.
Taking cimetidine with paroxetine can increase the level of paroxetine in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your paroxetine dose or may suggest an alternative to cimetidine.
Digoxin (Digitek, Lanoxin)
Taking paroxetine and digoxin together may decrease the level of digoxin in your blood. Your healthcare provider may need to adjust your digoxin dose when you are starting or stopping paroxetine.
Taking paroxetine with fentanyl can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together, and contact him or her right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
Intravenous Methylene Blue
Taking paroxetine with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.