Depression Home > Drug Interactions With Paroxetine

Paroxetine can interact with a number of drugs, including warfarin, lithium, and nonsteroidal anti-inflammatory drugs (such as ibuprofen). Some of these drug interactions with paroxetine can lead to problems such as stomach bleeding, increased drowsiness, or a very dangerous combination of symptoms called serotonin syndrome.

This article refers to the original, immediate-release paroxetine products (Paxil). Paroxetine is also the active ingredient in a few other products. For information about these other paroxetine products, please see:
 
 

Drug Interactions With Paroxetine: An Introduction

Paroxetine hydrochloride (Paxil®) can potentially interact with a number of drugs. Some of the drugs that can lead to paroxetine interactions include:
 

 

  
  • Monoamine oxidase inhibitors (MAOIs), including:

 

 

  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

 

 

  • Phenothiazine medications, including:

 

 

 

 

 

 

 

  
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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