Depression Home > Paxil CR Drug Interactions

There are a number of medications that can potentially interact with Paxil CR. Some of these drugs include aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), digoxin, and cimetidine. Paxil CR drug interactions may alter the levels of some medicines in your blood or lead to serious side effects -- such as bleeding in the stomach or intestines, serotonin syndrome, or QT prolongation (a dangerous irregular heart rhythm).

Paxil CR Drug Interactions: An Introduction

Paxil CR® (paroxetine controlled release) can potentially interact with a number of other medicines. Some of the medicines that can lead to Paxil CR interactions include:


  • Monoamine oxidase inhibitors (MAOIs), including:



  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:



  • Phenothiazine medications, including:







Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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