Depression Home > Does Pexeva Cause Weight Gain?

It is possible to experience weight gain while taking Pexeva (paroxetine mesylate). In studies, weight gain was reported in more than 1 percent of people taking the drug. If you experience this side effect, let your doctor know so he or she can rule out certain medical conditions, prescribe another antidepressant, or recommend lifestyle changes, such as exercising more and limiting your alcohol intake.

Does Pexeva Cause Weight Gain?

Pexeva® (paroxetine mesylate) is a prescription medication used for the treatment of several mental health conditions. It belongs to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Although weight gain does not appear to be a common side effect of Pexeva, it was reported in clinical trials.

Weight Gain in Clinical Trials of Pexeva

Before medicines are approved, they must go through several clinical studies, where thousands of people are given different doses of the medication. In these trials, people report all their possible side effects, which are carefully documented and grouped into categories.
The side effects are then usually separated into those that occur in more than 1 percent of people (common side effects) and those that occur in less than 1 percent of people (rare side effects).
In clinical studies, up to 4 percent of people reported an increased appetite on Pexeva. This side effect appeared to be more common in people being treated for obsessive-compulsive disorder. Weight gain was reported as a frequent side effect, meaning it occurred in at least 1 percent of people. However, the exact percentage of people experiencing weight gain on Pexeva is not known.

Other Thoughts

It is important to keep in mind that some mental health conditions, including depression, can cause weight changes. Sometimes, people who are depressed eat more, which can lead to weight gain. Other times, they eat less, which can lead to weight loss.
If you have recently lost weight due to depression, treating the depression may appear to cause weight gain. This is because as the symptoms of depression go away and your appetite returns to normal, you may experience a small amount of weight gain.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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