Depression Home > Pexeva and Breastfeeding

Many experts consider it safe to breastfeed while taking Pexeva (paroxetine mesylate). Although the drug has been shown to pass through breast milk, it generally does so in very small amounts. However, because every woman's situation is different, talk to your healthcare provider for a recommendation in your particular situation.

Is Pexeva Safe While Breastfeeding?

Pexeva® (paroxetine mesylate) is known to pass through breast milk in small amounts. However, the effects on a nursing child are not entirely known.
Because of the potential for serious side effects, it is generally recommended that healthcare providers look at the possible risks and benefits before recommending Pexeva while breastfeeding. Therefore, if you are breastfeeding while taking this drug, or are even considering it, make sure to let your healthcare provider know.

More Information on Breastfeeding and Pexeva

Pexeva passes through breast milk in such small amounts that a nursing child would likely ingest very little of the medication. Several studies have shown that when a woman takes paroxetine (the active ingredient in Pexeva) while breastfeeding, very little or none of the drug is found in the child's body.
However, side effects have been reported in nursing children whose mothers were taking paroxetine. These side effects included irritability, constipation, and difficulty feeding. In most of these cases, the mothers also took paroxetine during pregnancy, making it difficult to determine if the infants' effects were due to taking the drug during breastfeeding or during pregnancy.
The recommendations for breastfeeding and Pexeva use are not clear-cut, unfortunately. Many experts consider the drug safe for use during breastfeeding. However, because the long-term effects on a nursing child are unknown, some experts recommend stopping or reducing the frequency of breastfeeding during treatment. The American Academy of Pediatrics considers Pexeva a medicine for which the effects on a nursing infant are unknown, but potentially concerning. 
If you and your healthcare provider determine that it is okay to breastfeed while you are taking this drug, be sure to watch for any potential side effects in your child. These may include sedation, irritability, difficulty feeding, or constipation.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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