Depression Home > Pexeva and Sexual Side Effects

People taking Pexeva (paroxetine mesylate) should be aware that sexual side effects are a possibility. For example, ejaculation problems occurred in up to 28 percent of men taking the drug in clinical studies where side effects were reported. Other potential sexual side effects include erectile dysfunction and a decreased interest in sex. If you develop any of these problems, talk to your healthcare provider.

Does Pexeva Cause Sexual Side Effects?

Pexeva® (paroxetine mesylate) is a prescription medication used for the treatment of several mental health conditions. It belongs to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Just like all SSRIs, Pexeva may cause sexual side effects, including:
  • A decreased interest in sex, also called decreased libido or sex drive
  • Ejaculation or orgasm problems
  • Impotence (also known as erectile dysfunction, or ED)
  • Priapism, a painful erection that lasts for hours.
Decreased Libido
Decreased libido is a term used to describe a reduced sex drive. If a person has decreased libido, they may find they are not as interested in sexual activity, or they don't think about sex as much as before, if at all. If these feelings persist, they can be worrisome for both the person with the decreased libido and their sexual partner.
Pexeva is known to cause a decrease in sex drive. In clinical studies where side effects were documented, a decreased sex drive occurred in up to 15 percent of men taking Pexeva and up to 9 percent of women.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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