Depression Home > Protriptyline Side Effects

Serious Protriptyline Side Effects

Some side effects with protriptyline are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 
 
  • Change in heart rhythm (arrhythmia)
 
  • Fast heart rate (tachycardia) or feelings of a rapidly or forcefully beating heart (palpitations)
 
 
  • Confusion, delusions, or hallucinations
 
  • Signs of an allergic reaction, including:
 
    • Unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
 
  • Any breast changes, including breast enlargement or breast discharge
 
  • Swelling of the testicles
 
  • Yellowing of the eyes or skin (jaundice)
 
 
  • Hostility or aggressiveness
 
  • Engaging in unusual or dangerous activities
 
  • Restlessness or inability to sit still
 
  • Extreme elation or feelings of happiness that may switch back and forth with a depressed or sad mood
 
  • Other unusual changes in behavior
 
  • Difficulty sleeping
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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