Depression Home > Prozac Drug Interactions

When Prozac is taken with lithium, certain seizure medications, triptans, or other medications, drug interactions could occur. When these interactions occur, drug levels in your blood can increase significantly and your risks for developing side effects (such as stomach bleeding or serotonin syndrome) may be higher. Other medications that may potentially lead to drug interactions with Prozac include diazepam, monoamine oxidase inhibitors, warfarin, and nonsteroidal anti-inflammatory drugs.

Drug Interactions With Prozac: An Introduction

Prozac® (fluoxetine hydrochloride) can potentially interact with a number of medicines. Some of the medicines that can lead to interactions with this product include:



  • Monoamine oxidase inhibitors (MAOIs), including:



  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:



  • Other SSRI or SNRI medications, such as:






Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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