Depression Home > When Does Prozac Start Working?

Many people may wonder, "When does Prozac® (fluoxetine hydrochloride) start working?" It usually takes several weeks (and maybe even longer) to feel the full, beneficial effects of Prozac. Try not to be discouraged if the drug does not work right away for you. For Prozac to work properly, you have to take it as prescribed. The medication will not work if you take it in a way other than how your healthcare provider prescribes. It is also important to take Prozac at the same time every day to maintain an even level of the medication in your blood.
If Prozac makes you drowsy, try taking your dosage before bedtime. If it causes insomnia for you, try taking it in the morning. You can take Prozac with or without food. If the antidepressant bothers your stomach, try taking it with food. Make sure to talk to your healthcare provider before stopping Prozac, as stopping the medication too quickly may cause withdrawal symptoms.
If you are unsure about anything related to your dosage or Prozac dosing in general, please talk with your doctor, nurse, or pharmacist.
(For more information, click Prozac Dosage. This article also discusses Prozac dosing guidelines for treating various conditions, as well as factors that may affect your dosage.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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