Depression Home > Tofranil Drug Interactions

If alcohol, blood pressure medications, or thyroid medications are taken with Tofranil, drug interactions may occur. These interactions can increase or decrease drug levels in your blood and may lead to dangerous side effects, such as QT prolongation and suicidal thoughts. To reduce the risk of developing drug interactions with Tofranil, let your healthcare provider know if you are taking any other medications before starting the antidepressant.

Tofranil Drug Interactions: An Introduction

Tofranil® (imipramine hydrochloride) can potentially interact with many medicines. Some of the medicines that may lead to Tofranil drug interactions include:
  • Barbiturates, including:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
  • Phenytoin (Dilantin®)
  • Pressors, including:
    • Dopamine (Intropin®)
    • Dobutamine (Dobutrex®)
    • Epinephrine (Adrenalin®, EpiPen®)
    • Norepinephrine (Levophed®)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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