Depression Home > Drug Interactions With Trazodone

Trazodone and Serotonin Syndrome

Several of the known interactions with trazodone are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.

More Details on Drug Interactions With Trazodone

The following sections explain in detail the potentially negative interactions that can occur when trazodone is combined with any of the drugs listed above.
Anticoagulant or Antiplatelet Medications
Combining trazodone with medications that "thin" the blood (medications with anticoagulant or antiplatelet properties) could increase the risk of bleeding. Check with your healthcare provider before taking trazodone with any of these medications.
Additionally, trazodone may interact unpredictably with warfarin.
Blood Pressure Medications
Sometimes, combining trazodone with a high blood pressure medication may cause low blood pressure (hypotension). Watch for symptoms such as lightheadedness, dizziness, or fainting. In some cases, your healthcare provider might need to lower the dosage of your blood pressure medication.
Because combining trazodone with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
CYP 3A4 Inhibitors
Trazodone is broken down (metabolized) by certain enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors slow down these enzymes, potentially leading to high levels of trazodone in the bloodstream, perhaps increasing the risk of trazodone side effects. Check with your healthcare provider before combining such medications. In some cases, a lower-than-normal trazodone dosage may be necessary.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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