Depression Home > Drug Interactions With Trazodone

Tramadol
Taking trazodone with tramadol can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see Precautions and Warnings With Trazodone), as it can be very dangerous.
 
Tricyclic Antidepressants
Taking trazodone with tricyclic antidepressants can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see Precautions and Warnings With Trazodone), as it can be very dangerous.
 
Triptans
Taking trazodone with a triptan can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see Precautions and Warnings With Trazodone), as it can be very dangerous.
 
Tryptophan
Taking trazodone with tryptophan can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see Precautions and Warnings With Trazodone), as it can be very dangerous.
 

Final Thoughts on Drug Interactions With Trazodone

It is possible that not all drug interactions with trazodone were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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