Depression Home > Trazodone for Depression

If you are an adult dealing with depression, your healthcare provider may recommend a drug called trazodone hydrochloride (Desyrel®). In large clinical trials, this antidepressant has been shown to improve symptoms of depression (also called major depression or clinical depression), such as:
  • Sleeping too much
  • Not sleeping enough
  • Eating too much
  • Eating too little
  • Having little interest in things that you used to enjoy.
Like selective serotonin reuptake inhibitors (SSRIs), trazodone is thought to work for depression by balancing levels of a certain chemical within the brain called serotonin. However, unlike SSRIs, it may also block certain serotonin receptors.
If you are taking trazodone, keep in mind that many antidepressants can take several weeks to begin working. Sometimes, other people will notice an improvement in your symptoms before you do. Often, the physical symptoms of depression (such as pain or changes in sleep) will improve first -- sometimes within the first few weeks of treatment.
(For more information on this depression drug, click Trazodone. This article describes the uses and effects of this drug in more detail and lists some important safety issues to keep in mind.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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