Depression Home > What Is Trazodone Used For?

How Trazodone Works

It is not entirely clear how trazodone works, since no other medications work exactly like it. Trazodone acts on a specific chemical within the brain known as serotonin. This is one of several chemicals used to send messages in between nerves; however, when serotonin levels become unbalanced, it can cause a variety of conditions, including depression. Trazodone helps to block the reuptake of serotonin so that more is available for the nerves in the brain, returning the serotonin back to its "normal" levels. However, unlike selective serotonin reuptake inhibitors (SSRIs), trazodone may also block certain serotonin receptors.

Is Trazodone Used for Children?

Trazodone is not approved for use in childhood depression. Talk to your healthcare provider about the risks and benefits of using the drug in children with depression.

Is Trazodone Used for Off-Label Purposes?

On occasion, your healthcare provider may recommend trazodone for treating something other than depression. This is called an "off-label" use. At this time, there are several off-label uses for trazodone, including the treatment of:
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Last reviewed by: Kristi Monson, PharmD;
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