Depression Home > Uses of Tricyclic Antidepressants
Although tricyclic antidepressants are primarily approved to treat depression, some of them are approved for additional uses, such as bedwetting, obsessive-compulsive disorder, psychotic depression, and anxiety. There are also several off-label uses of tricyclic antidepressants, such as treating chronic pain, preventing migraines, and helping people quit smoking.
Uses of Tricyclic Antidepressants: An OverviewEvery tricyclic antidepressant (TCA) except clomipramine is approved for the treatment of depression. However, a few antidepressants are approved for additional uses, including:
- Bedwetting in children -- imipramine hydrochloride (Tofranil®)
- Obsessive-compulsive disorder (OCD) -- clomipramine (Anafranil®)
- Psychotic depression (depression with hallucinations, delusions, or other psychotic features) -- amoxapine (Asendin®)
- Anxiety -- doxepin (Sinequan®) is approved to treat anxiety, and several of the tricyclic antidepressants are approved to treat anxiety associated with depression.
- Insomnia -- low-dose doxepin (Silenor®) is approved for the treatment of insomnia characterized by difficulty staying asleep (as opposed to difficulty falling asleep).