Depression Home > Wellbutrin and Dry Mouth

There are a number of possible side effects of Wellbutrin, and dry mouth appears to be one of the most common. In previous studies, up to 27.6 percent of people taking Wellbutrin reported a dry mouth as a side effect of the medication. Some suggestions on how to improve a dry mouth include sipping water or sugarless drinks often, avoiding drinks with caffeine, and using a humidifier at night.

Wellbutrin and Dry Mouth: An Overview

Dry mouth is one of the most common side effects of Wellbutrin® (bupropion hydrochloride). In previous studies, up to 27.6 percent of people taking Wellbutrin reported dry mouth as a side effect of the medication, compared to 18.4 percent of people who were not taking Wellbutrin.

Wellbutrin and Dry Mouth: Recommendations

If you are taking Wellbutrin and dry mouth becomes a problem, there are a number of things that you can do. Some of these suggestions include:
  • Sipping water or sugarless drinks often.
  • Sipping water or sugarless drinks during meals. This will make chewing and swallowing easier. It may also improve the taste of the food.
  • Avoiding drinks with caffeine, such as coffee, tea, and some sodas. Caffeine can dry out the mouth.
  • Avoiding tobacco and alcohol, as they dry out the mouth.
  • Using a humidifier at night.
  • Being aware of spicy or salty foods. These may cause pain in a dry mouth.
  • Chewing sugarless gum or sucking on sugarless, hard candy to stimulate saliva flow; cinnamon or mint-flavored candies are good choices.

Wellbutrin and Dry Mouth: Summary

If you experience a dry mouth while taking Wellbutrin and the suggestions above do not help, be sure to talk with your healthcare provider. There are treatments that he or she may be able to recommend, such as artificial saliva. Also, depending on the severity of your Wellbutrin dry mouth, he or she may also recommend that you adjust your Wellbutrin dosage or try another depression medicine.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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