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Zoloft and Serotonin Syndrome

Several of the known interactions with Zoloft are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
 
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
 
Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.
 

Zoloft Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Zoloft is combined with any of the drugs listed above.
 
Alcohol
According to the prescribing information, drinking alcohol while taking Zoloft is not recommended. Combining the two may cause unwanted side effects (see Alcohol and Zoloft).
 
Aspirin
Taking Zoloft and aspirin together can increase your risk of stomach bleeding. Talk to your healthcare provider before combining these medications.
 
Buspirone (BuSpar)
Because combining Zoloft with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
 
Certain Arrhythmia Medications
Taking Zoloft with certain arrhythmia medications can increase the level of arrhythmia medication in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor you more closely and adjust your dose of these medications.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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