Depression Home > Zoloft Drug Interactions
Zoloft and Serotonin Syndrome
Several of the known interactions with Zoloft are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
- Fast heartbeat
- Feeling faint
- Muscle spasm
- Difficulty walking
Zoloft Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when Zoloft is combined with any of the drugs listed above.
According to the prescribing information, drinking alcohol while taking Zoloft is not recommended. Combining the two may cause unwanted side effects (see Alcohol and Zoloft).
Taking Zoloft and aspirin together can increase your risk of stomach bleeding. Talk to your healthcare provider before combining these medications.
Because combining Zoloft with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
Certain Arrhythmia Medications
Taking Zoloft with certain arrhythmia medications can increase the level of arrhythmia medication in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor you more closely and adjust your dose of these medications.