Depression Home > Zoloft Drug Interactions

Cimetidine (Tagamet)
Combining cimetidine and Zoloft can increase the level of Zoloft in your blood, possibly increasing your risk of side effects. Your healthcare provider may need to lower your Zoloft dosage or may suggest an alternative to cimetidine.
Digoxin (Digitek, Lanoxin)
Taking Zoloft and digoxin together may increase your risk of side effects with either drug. Your healthcare provider may need to adjust your dose of these medications to prevent interactions from occurring.
Disulfiram (Antabuse)
You should not take Zoloft oral concentrate (the liquid version) while taking disulfiram. Because the oral concentrate contains 12 percent alcohol, taking it with disulfiram will cause severe side effects.
Combining Zoloft with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
Intravenous Methylene Blue
Taking Zoloft with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
Linezolid (Zyvox)
Combining Zoloft with a linezolid can cause a group of symptoms called serotonin syndrome. These symptoms may include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Talk to your healthcare provider before taking Zoloft and a linezolid. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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