Depression Home > Zoloft Drug Interactions

Lithium (Eskalith, Lithobid)
Combining Zoloft and lithium can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see the previous paragraph), as it can be dangerous.
 
Miscellaneous Antidepressants
Combining Zoloft with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors (MAOIs)
Taking Zoloft and an MAOI together can cause life-threatening side effects. Never take these medications at the same time, and do not take them within two weeks of each other.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Combining Zoloft and NSAIDs can increase your risk of stomach bleeding. Talk to your healthcare provider before taking these medicines together.
 
Pimozide (Orap)
Do not take pimozide and Zoloft together, as the combination may cause a dangerous irregular heart rhythm (arrhythmia) called QT prolongation.
 
SSRI or SNRI Antidepressants
Taking Zoloft with other SSRI or SNRI antidepressants can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these depression medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
St. John's Wort
Combining Zoloft with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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