Depression Home > Zoloft for Depression

Zoloft® (sertraline hydrochloride) is a prescription medicine licensed to treat a number of conditions within the brain. Most people take Zoloft for depression, but the antidepressant is also approved for the treatment of:
When the levels of serotonin (a chemical in the brain) become unbalanced, it can cause a variety of conditions, including depression and panic disorder. Zoloft works to improve symptoms of depression by blocking the reuptake of serotonin so that more remains in the space between the brain's nerve cells.
Before you begin using Zoloft for depression or other conditions, make sure to talk to your healthcare provider if you are pregnant, have diabetes, or have bipolar disorder (or a family history of bipolar disorder).
(Click Zoloft to learn about the specific effects of this medicine, for more information on how it works, and to find out what side effects may occur with Zoloft.)
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Last reviewed by: Kristi Monson, PharmD;
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