Depression Home > Zoloft

Alternatives to Zoloft

Depression, even in its most severe form, is highly treatable. As with many illnesses, getting depression treatment early is more effective and reduces the chance of recurrence.
The most common forms of treatment for depression are medication (antidepressants) and psychotherapy ("talk therapy"). In cases of severe depression, healthcare providers may recommend electroconvulsive therapy (ECT). Some people may also try complementary or alternative treatments (see Natural Remedies for Depression).
For most people, Zoloft is quite effective at treating depression. It is also generally well tolerated. However, side effects can occur, or the medicine may not work as well as needed. In these cases, your healthcare provider may recommend an alternative to Zoloft. Some examples of substitute depression medications include:
(Click Zoloft Alternatives to learn more. Click Dealing With Depression for information about other ways of managing this condition.)

What If I Take an Overdose?

People who take too much Zoloft may have overdose symptoms that could include:
  • Drowsiness
  • Nausea and vomiting
  • Rapid heart rate (tachycardia) or slow heart rate (bradycardia)
  • Dizziness
  • Agitation
  • Shakiness (tremor)
  • Irregular heart rhythm (arrhythmia)
  • Seizures
  • Coma
  • Hallucinations (seeing, feeling, or hearing things that aren't really there)
  • High blood pressure (hypertension) or low blood pressure (hypotension)
  • Fainting
  • Inflammation of the pancreas (pancreatitis).
If you happen to take too much of the drug, seek immediate medical attention.
(Click Zoloft Overdose for more information.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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