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Nardil Drug Interactions

Several medications should not be taken with Nardil. Drug interactions may occur if the antidepressant is taken with blood pressure medications; stimulants; most cough, cold, and allergy products; or pressors. These interactions can lead to life-threatening side effects, such as dangerously high blood pressure. Before starting Nardil, tell your healthcare provider about all other medicines you are taking to minimize the risk of developing Nardil drug interactions.

 

Nardil Drug Interactions: An Overview

 Nardil® (phenelzine sulfate) can potentially interact with many medicines. Because so many Nardil drug interactions can be dangerous, it is important to check with your healthcare provider before taking any medication, whether prescription or over-the-counter. Make sure to tell all your healthcare providers (including dentists and surgeons) that you are taking Nardil. Some of the medicines that may lead to Nardil interactions include:
 
  • Apraclonidine eye drops (Iopidine®)
 
 
 
  • Barbiturates, such as:
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®)
 
  • Brimonidine eye drops (Alphagan P®)
 
 
 
  • Caffeine
 
 
  • Cough, cold, and allergy products, such as:
o Dextromethorphan (Robitussin DM® and many others)
o Naphazoline (various nasal and eye drops, such as Visine-A®)
o Oxymetazoline (various nasal and eye drops, such as Afrin®)
o Phenylephrine (Sudafed PE® and many others)
o Propylhexedrine (Benzedrex®)
o Psuedoephedrine (Sudafed® and many others)
 
  • Disulfiram (Antabuse®)
 
 
 
  • Methyldopa (Aldomet®, Aldoril®)
 
  • Meperidine (Demerol®)
 
 
  • Other monoamine oxidase inhibitors (MAOIs), including:
  • Narcotics, such as codeine, hydrocodone, morphine, and others
 
  • Pressors, including:
o Dopamine
o Ephedrine
o Epinephrine (Adrenalin®, EpiPen®, Primatene Mist®)
o Isometheptene (Duradrin®, Midrin®, Migquin®, Migratine®, Migrazone®, Migrin-A®)
o Levonordefrin (Carbocaine with Neo-Cobefrin®)
o Midodrine (Orvaten®, ProAmatine®)
o Norepinephrine (Levophed®)
  • Reserpine
 
 
  • Stimulants, such as:
o Dextroamphetamine (Dexedrine®, Dexedrine Spansules®)
o Phentermine (Adipex-P®, Ionamin®)
 
o Amitriptyline and chlordiazepoxide (Limbitrol®)
o Amitriptyline and perphenazine (Ertrafon®)
(Nardil Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;