Nardil Warnings and Precautions

Specific Nardil Warnings and Precautions

Some precautions and warnings to be aware of prior to starting treatment with Nardil include the following:
  • Nardil should be used only after other treatments have failed. Anyone taking the drug should be under close supervision of their healthcare provider.
  • Nardil has several potentially lethal food and drug interactions. In order to ensure a safe treatment process, you must commit to avoiding many foods and medications, including several non-prescription medications. Always check with your healthcare provider before taking any medications (see Nardil Drug Interactions and Nardil Food Interactions for more information).
  • Nardil can cause hypertensive crisis, which is a life-threatening increase in blood pressure. Tell your healthcare provider right away if you have symptoms of a hypertensive crisis, such as:
    • Headaches
    • Feelings of a rapidly or forcefully beating heart (palpitations)
    • Sore or stiff neck
    • Nausea or vomiting
    • Sweating, with a high fever (or sometimes with cold, clammy skin)
    • Sensitivity to light
    • Rapid heart rate (tachycardia) or low heart rate (bradycardia)
    • Chest pain or throat tightness
    • Dilated (wide open) pupils.
  • Antidepressants (including Nardil) may increase the risk of suicidal thinking or behavior in (see Depression and Suicide). Therefore, if you notice any changes in symptoms or new symptoms, talk to your healthcare provider immediately. Some of these symptoms may include:
    • Anxiety
    • Hostility
    • Agitation
    • Panic
    • Restlessness
    • Hallucinations
    • Extreme hyperactivity
  • Nardil may make schizophrenia worse. If you have schizophrenia, talk with your healthcare provider before taking the drug.
  • Before prescribing Nardil for depression, your healthcare provider should make sure that you do not have bipolar disorder instead. Sometimes, the symptoms of bipolar disorder and depression can appear similar, and Nardil can cause problems in people with bipolar disorder.
  • Be sure to tell all your healthcare providers (including dentists and surgeons) that you are taking Nardil.
  • The medication should be used cautiously in people with diabetes, as Nardil may make these people more sensitive to insulin. Your healthcare provider may recommend monitoring your blood sugar more closely or adjusting your dose of diabetes medication.
  • In addition to causing dangerously high blood pressure, Nardil can cause low blood pressure (hypotension). Let your healthcare provider know if you have symptoms of low blood pressure, such as lightheadedness, dizziness, or fainting.
  • For people taking Nardil, caution should be used when driving, operating heavy machinery, or performing other tasks that require concentration, especially when first starting the drug or when switching dosages. Nardil may affect a person's mental or physical ability to perform these tasks. Make sure that you understand how the drug affects you before performing any tasks that require mental or physical concentration.
  • Nardil may not be safe for use during pregnancy. Discuss the benefits and risk of using the drug while pregnant with your healthcare provider (see Nardil and Pregnancy).
  • It is not known if Nardil passes through breast milk. Therefore, if you are breastfeeding or plan to start, talk to your healthcare provider about what makes most sense for your particular situation (see Nardil and Breastfeeding).
  • Special care should be used when taking Nardil if you have a history of seizures, as the drug can make seizures worse.
  • Elderly people appear to be more sensitive to Nardil, and certain Nardil side effects may be more dangerous in these people.
  • Nardil can cause low blood sugar (hypoglycemia) in people taking diabetes medications. When starting Nardil or changing dosages, make sure to check your blood sugar levels more often.
  • Do not stop taking Nardil without first discussing it with your healthcare provider. Stopping the medicine abruptly may increase the risk for withdrawal symptoms (see Nardil Withdrawal).
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