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from eMedTV.comNefazodone Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when nefazodone is combined with any of the drugs listed above.
Alcohol
It is not recommended to drink alcohol while taking nefazodone. Combining alcohol and nefazodone together may cause unwanted side effects (see Alcohol and Serzone).
Alprazolam (Xanax)
Nefazodone can double the level of alprazolam in your blood, increasing your risk of side effects. Your healthcare provider should reduce your alprazolam dose by half if you are taking nefazodone.
Buspirone (BuSpar)
Taking buspirone and nefazodone together can increase the level of buspirone in your blood and put you at higher risk for side effects. Your healthcare provider may need to decrease your buspirone dose.
Carbamazepine (Tegretol, Tegretol XR)
Carbamazepine can greatly decrease the level of nefazodone in your blood, perhaps making nefazodone less effective. It is generally not recommended to take these medications together.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Nefazodone can increase the level of cyclosporine in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor the level of cyclosporine in your blood.
Digoxin (Lanoxin, Digitek)
Taking digoxin with nefazodone may increase the level of digoxin in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor the level of digoxin in your blood, especially when starting or stopping nefazodone.
Fluoxetine (Prozac, Sarafem)
Taking nefazodone and fluoxetine together can change the way your body metabolizes nefazodone, increasing your chance of side effects. Talk to your healthcare provider before taking these medications together (or even within several weeks of each other).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD