Nefazodone has been studied in many clinical trials for the treatment of depression. In theses studies, people taking nefazodone had more improvement in their depression symptoms than those not taking the medication. This was also shown to be true for people who were hospitalized for their depression. Two long-term studies have shown that the medication can also reduce the chance of depression relapse.

When and How to Take Nefazodone

Some general considerations for when and how to take the medication include:
  • Nefazodone comes in tablet form. It is taken by mouth, usually twice a day.
  • You can take it with or without food. If the drug bothers your stomach, try taking it with food.
  • Nefazodone should be taken at the same times each day to maintain an even level of the drug in your blood.
  • For the medication to work properly, it must be taken as prescribed. It will not work if you stop taking it.


The dose of nefazodone that your healthcare provider recommends will vary depending on a number of factors, including:
  • Your age
  • Other medical conditions you may have
  • Other medications you may currently be taking.
As with any medication, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Nefazodone Dosing for more information.)

Drug Interactions

Nefazodone can potentially interact with a number of medicines.
(Click Drug Interactions With Nefazodone for more information.)
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Nefazodone (Serzone)

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