Drug Interactions With Nortriptyline

The following sections explain in detail the potentially negative interactions that can occur when nortriptyline is combined with any of the drugs listed above.

 

Nortriptyline may enhance the effects of alcohol. This can lead to an increased risk for suicidal thoughts and other nortriptyline overdose symptoms. Make sure to talk with your healthcare provider about drinking alcohol while taking nortriptyline.

 

Taking nortriptyline with anticholinergic medications may cause increased side effects. Talk to your healthcare provider before using these medications together, as your dosages may need to be reduced. Since some of these types of medicines are found in over-the-counter medicines, do not treat yourself for the common cold, a cough, or allergies without first talking to your healthcare provider.

 

Taking nortriptyline with arrhythmia medications can increase your risk of a dangerous arrhythmia called QT prolongation. Also, certain arrhythmia medications can increase the level of nortriptyline in your blood, increasing your risk of side effects. Talk to your healthcare provider before taking these medications together.

 

Taking nortriptyline with barbiturates can increase the risk of side effects of both nortriptyline and barbiturates, such as drowsiness or dizziness. Your healthcare provider may need to adjust your dose of these medications.

 

There has been one report of a person experiencing low blood sugar (hypoglycemia) after taking chlorpropamide and nortriptyline together. Your healthcare provider may need to monitor your blood sugar more closely, especially when starting or stopping nortriptyline.