Drug Interactions With Nortriptyline

Phenothiazines
Taking nortriptyline with phenothiazine medications can increase the level of nortriptyline in your blood, increasing your risk of side effects. Also, combining nortriptyline with certain phenothiazines can increase your risk of a dangerous irregular heart rhythm called QT prolongation. Talk to your healthcare provider before taking these medications together.
 
Pressors
Taking nortriptyline with pressor medications can increase your risk of side effects. Your healthcare provider may need to adjust your dose of these medications.
 
SSRIs or SNRIs
Taking nortriptyline with SSRIs or SNRIs can increase the level of nortriptyline in your blood, increasing your chance of side effects and increasing the risk for serotonin syndrome. Your healthcare provider may need to adjust your dose of these medications or use caution when switching from one medicine to another.
 
St. John's Wort
Combining nortriptyline with St. John's wort may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Thyroid Medications
Taking nortriptyline with thyroid medications can increase your risk of nortriptyline side effects. Your healthcare provider may need to adjust your dose of these medications.
 
Tramadol
Combining nortriptyline with tramadol may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Tricyclic Antidepressants
Taking nortriptyline with other tricyclic antidepressants can increase your risk of side effects. Your healthcare provider may need to adjust your dose of these medications.
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