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Drug Interactions With Nortriptyline

When thyroid medications, alcohol, or certain antidepressants are taken together with nortriptyline, interactions may occur. When a drug interaction with nortriptyline occurs, the levels of nortriptyline and other medications in your blood can increase, potentially increasing your risk of side effects. Therefore, be sure to talk to your healthcare provider about possible nortriptyline drug interactions that may apply to your situation.

 

Drug Interactions With Nortriptyline: An Introduction

 Nortriptyline hydrochloride (Pamelor®) can potentially interact with many medicines. Some of the medicines that may lead to nortriptyline interactions include:
 
  • Alcohol
     
  • Anticholinergic medications, including:
o Atropine
o Belladonna (Donnatal®, B&O Supprettes®, Bellamine S®)
o Clidinium (Librax®)
o Diphenhydramine (Benadryl®, Tylenol PM®)
o Glycopyrrolate (Robinul®)
o Homatropine (Hycodan®)
o Hyoscyamine (Levsin®)
o Scopolamine (Transderm Scop®)
  • Arrhythmia medications, including:
o Amiodarone (Cordarone®)
o Disopyramide (Norpace®)
o Dofetilide (Tikosyn®)
o Flecainide (Tambocor®)
o Ibutilide (Corvert®)
o Propafenone (Rythmol®)
o Quinidine
o Sotalol (Betapace®) 
  • Barbiturates, including:
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®) 
  • Chlorpropamide (Diabinese®)
     
  • Cimetidine (Tagamet®)
     
  • Monoamine oxidase inhibitors (MAOIs), including:
  • Phenothiazine medications, including:
o Promethazine (Phenergan®)
  • Pressors, including:
o Dopamine (Intropin®)
o Dobutamine (Dobutrex®)
o Epinephrine (Adrenalin®, EpiPen®)
o Norepinephrine (Levophed®)
  • Thyroid medications, including:
o Liotrix (Thyrolar®)
o Levothyroxine (Levoxyl®, Synthroid®, Unithroid®)
o Thyroid (Armour® Thyroid, Nature-Throid®)
(Drug Interactions With Nortriptyline Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;