Nortriptyline hydrochloride (
Pamelor®) is a prescription medicine licensed to treat
depression. If you have recently started treatment with this
antidepressant, you may be wondering, "When does nortriptyline start working?"
Antidepressants such as nortriptyline may take several weeks to start working. In most cases, the physical
symptoms of depression (such as pain or changes in sleep patterns) will improve first, sometimes within the first few weeks of treatment. It usually takes a few weeks before significant changes in mood occur.
For nortriptyline to work properly, you have to take it as prescribed. The antidepressant will not work if you take it differently than your healthcare provider prescribes. It should be taken at the same time each day to maintain an even level of the medication in your blood.