When Does Nortriptyline Start Working?

Nortriptyline hydrochloride (Pamelor®) is a prescription medicine licensed to treat depression. If you have recently started treatment with this antidepressant, you may be wondering, "When does nortriptyline start working?"
Antidepressants such as nortriptyline may take several weeks to start working. In most cases, the physical symptoms of depression (such as pain or changes in sleep patterns) will improve first, sometimes within the first few weeks of treatment. It usually takes a few weeks before significant changes in mood occur.
For nortriptyline to work properly, you have to take it as prescribed. The antidepressant will not work if you take it differently than your healthcare provider prescribes. It should be taken at the same time each day to maintain an even level of the medication in your blood.
(Click What Is Nortriptyline Used For? and Nortriptyline Dosing for more information on when nortriptyline may start working, for detailed dosing guidelines for the treatment of depression, and for tips on using it safely.)
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