Drug Interactions With Olanzapine and Fluoxetine

Olanzapine and Fluoxetine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when olanzapine and fluoxetine is combined with any of the drugs listed above.

 

People are generally advised not to drink alcohol while taking olanzapine and fluoxetine. Combining the two may cause unwanted side effects (see Alcohol and Symbyax).

 

Taking olanzapine and fluoxetine with alprazolam can increase the level of alprazolam in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of alprazolam to prevent this interaction from occurring.

 

If olanzapine and fluoxetine is taken with aspirin, it can increase your risk of stomach bleeding. Talk to your healthcare provider before taking these medications together.

 

Taking olanzapine and fluoxetine with carbamazepine can lower the amount of olanzapine and fluoxetine in your blood, perhaps decreasing its effectiveness. It can also increase the amount of carbamazepine in your blood, increasing your risk of side effects. Your healthcare provider may need to adjust your dose of these medications to prevent this from happening.

 

Olanzapine and fluoxetine can increase the level of certain antipsychotic medications in your blood and can increase your risk of side effects. Your healthcare provider may need to lower your dose of the antipsychotic medicine to prevent this.

 

Thioridazine should never be taken with olanzapine and fluoxetine. In fact, you should not take thioridazine if you have taken olanzapine and fluoxetine within the past five weeks.