Drug Interactions With Olanzapine and Fluoxetine

Medications That Prolong the QT Interval
Many different medications, including olanzapine and fluoxetine, can cause a change in the heart rhythm known as QT prolongation, which can be very dangerous. Combining olanzapine and fluoxetine with other QT-prolonging medications increases the risk of a life-threatening arrhythmia (torsade de pointes) caused by excessive QT prolongation. Check with your healthcare provider before combining such medications.
 
Mexiletine
Taking olanzapine and fluoxetine with mexiletine can raise the amount of olanzapine and fluoxetine in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to adjust your doses of them to prevent interactions from occurring.
 
Miscellaneous Antidepressants
Combining olanzapine and fluoxetine with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors
Combining olanzapine and fluoxetine with an MAOI can cause life-threatening side effects. Never take an MAOI and olanzapine and fluoxetine at the same time, and do not take olanzapine and fluoxetine if you have taken an MAOI within the past 14 days. Also, because olanzapine and fluoxetine stays in your system for so long, do not take an MAOI if you have taken olanzapine and fluoxetine within the past five weeks.
 
Nonsteroidal Anti-Inflammatory Drugs
Taking olanzapine and fluoxetine and NSAIDs together can increase your risk of stomach bleeding. Talk to your healthcare provider before combining these two medications.
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