Drug Interactions With Olanzapine and Fluoxetine

Norfloxacin
If olanzapine and fluoxetine is taken with norfloxacin, it can raise the amount of olanzapine and fluoxetine in your blood, potentially increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to adjust your doses of them to prevent drug interactions from occurring.
 
Ofloxacin
Taking olanzapine and fluoxetine with ofloxacin can raise the amount of olanzapine and fluoxetine in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to adjust your doses of them to prevent interactions.
 
Olanzapine
Because olanzapine and fluoxetine already contains olanzapine, do not take these medications together without talking to your healthcare provider first.
 
Phenytoin
Taking olanzapine and fluoxetine with phenytoin can lower the amount of olanzapine and fluoxetine in your blood, perhaps decreasing its effectiveness. It can also increase the amount of phenytoin in your blood, increasing your risk of side effects. Your healthcare provider may need to adjust your dose of these medications to prevent drug interactions from occurring.
 
SSRI or SNRI Medications
Taking olanzapine and fluoxetine with SSRI or SNRI medications can cause serotonin syndrome. Talk to your healthcare provider before taking these depression medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be a dangerous condition.
 
In addition, taking olanzapine and fluoxetine with fluvoxamine can raise the amount of olanzapine and fluoxetine in your blood, possibly increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your olanzapine and fluoxetine dosage.
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