Oleptro Drug Interactions

When antiplatelet medications, nonsteroidal anti-inflammatory drugs, or monoamine oxidase inhibitors are taken with Oleptro, drug interactions may occur. These interactions can alter the level of Oleptro in your blood and increase your risk of side effects. Notify your healthcare provider immediately if you develop symptoms such as hallucinations, fever, or difficulty walking while taking this medication.

• Medications that "thin" the blood (such as anticoagulant and antiplatelet drugs), such as:
   
  • Antithrombin (ATryn^®, Thrombate III^®)
  • Apixaban (Eliquis^®)
  • Argatroban
  • Aspirin (Bayer^® and others)
  • Bivalirudin (Angiomax^®)
  • Cilostazol (Pletal^®)
  • Clopidogrel (Plavix^®)
  • Dabigatran etexilate mesylate (Pradaxa^®)
  • Dipyridamole (Persantine^®)
  • Drotrecogin alfa (Xigris^®)
  • Eptifibatide (Integrilin^®)
  • Fondaparinux (Arixtra^®)
  • Heparin or heparin-like products, including dalteparin (Fragmin^®), enoxaparin (Lovenox^®), or tinzaparin (Innohep^®)
  • Lepirudin (Refludan^®)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

• • • Celecoxib (Celebrex^®)
    • Diclofenac (Cambia™, Cataflam^®, Flector^®, Solaraze^® Gel, Voltaren^®, Voltaren^® Gel, Voltaren^®-XR, Voltaren Ophthalmic^®, Zipsor™)
    • Ibuprofen (Motrin^®, Advil^®, Nuprin^®)
    • Indomethacin (Indocin^®, Indocin SR^®)
    • Ketoprofen (Orudis^®, Actron^®, Oruvail^®)
    • Ketorolac (Toradol^®)
    • Meloxicam (Mobic^®)
    • Naproxen (Naprosyn^®) or naproxen sodium (Aleve^®, Anaprox^®, Naprelan^®)
    • Several others (see List of NSAIDs for a more complete list of these medications)

• • Pentoxifylline (Trental^®)
  • Prasugrel (Effient^®)
  • Rivaroxaban (Xarelto^®) 
  • Thrombolytics, such as:

• • • Alteplase (Activase^®)
    • Reteplase (Retavase^®)
    • Streptokinase (Streptase^®)
    • Tenecteplase (TNKase^®)

• • Ticagrelor (Brilinta^®)
  • Ticlopidine (Ticlid^®)
  • Tirofiban (Aggrastat^®)
  • Warfarin (Coumadin^®, Jantoven^®)

• Blood pressure medications  
• Buspirone (Buspar^®)
• CYP 3A4 inhibitor medications, including but not limited to:
   
  • Amprenavir (Agenerase^®)
  • Atazanavir (Reyataz^®)
  • Clarithromycin (Biaxin^®)
  • Conivaptan (Vaprisol^®)
  • Darunavir (Prezista^®)
  • Delavirdine (Rescriptor^®)
  • Erythromycin
  • Fosamprenavir (Lexiva^®)
  • Imatinib (Gleevec^®)
  • Indinavir (Crixivan^®)
  • Isoniazid
  • Itraconazole (Sporanox^®)
  • Ketoconazole (Nizoral^®)
  • Lopinavir and ritonavir (Kaletra^®)
  • Miconazole
  • Nefazodone (Serzone)
  • Nelfinavir (Viracept^®)
  • Nicardipine (Cardene^®)
  • Posaconazole (Noxafil^®)
  • Quinidine
  • Ritonavir (Norvir^®)
  • Saquinavir (Fortovase^®, Invirase^®)
  • Telithromycin (Ketek^®)
  • Voriconazole (VFEND^®)

• Carbamazepine (Tegretol^®, Tegretol XR^®)
• Digoxin (Lanoxin^®, Digitek^®)
• Fentanyl (Abstral^®, Actiq^®, Duragesic^®, Fentora^®, Lazanda^®, Onsolis^®, Subsys^®) 
• Intravenous methylene blue
• Linezolid (Zyvox^®)
• Lithium (Eskalith^®, Lithobid^®)

• Miscellaneous antidepressants, such as:

• • Bupropion (Aplenzin™, Budeprion XL^®, Budeprion™ SR, Buproban^®, Wellbutrin SR^®, Wellbutrin XL^®, Wellbutrin^®, Zyban^®)
  • Mirtazapine (Remeron^®)
  • Nefazodone (Serzone^®)
  • Immediate-release trazodone (Desyrel^®)
  • Vilazodone (Viibryd™)

• Monoamine oxidase inhibitors (MAOIs), including:
   
  • Isocarboxazid (Marplan^®)
  • Phenelzine (Nardil^®)
  • Rasagiline (Azilect^®)
  • Selegiline (Eldepryl^®, Emsam^®, Zelapar^®)
  • Tranylcypromine (Parnate^®)

• Phenytoin (Dilantin^®, Phenytek^®)
• Sibutramine (Meridia^®)
• SSRI or SNRI antidepressants, such as:
   
  • Citalopram (Celexa^®)
  • Duloxetine (Cymbalta^®)
  • Desvenlafaxine (Pristiq^®)
  • Escitalopram (Lexapro^®)
  • Fluoxetine (Prozac^®, Sarafem^®, Selfemra™)
  • Fluvoxamine (Luvox^®, Luvox^® CR)
  • Levomilnacipran (Fetzima™)
  • Milnacipran (Savella™)
  • Paroxetine (Paxil^®, Paxil CR^®, Pexeva^®, Brisdelle™)
  • Sertraline (Zoloft^®)
  • Venlafaxine (Effexor^®, Effexor^® XR)

• St. John's wort
• Tramadol (Rybix™ ODT, Ryzolt^®, Ultram^®, Ultram^® ER) or tramadol/acetaminophen (Ultracet^®)

• Triptans, including:
   
  • Almotriptan (Axert^®)
  • Eletriptan (Relpax^®)
  • Frovatriptan (Frova^®)
  • Naratriptan (Amerge^®)
  • Rizatriptan (Maxalt^®)
  • Sumatriptan (Alsuma™, Imitrex^®, Sumavel^®, Zecuity™) or sumatriptan/naproxen sodium (Treximet^®)
  • Zolmitriptan (Zomig^®)

• Tryptophan.