Pamelor Drug Interactions

Phenothiazines
Taking Pamelor with phenothiazine medications can increase the level of Pamelor in your blood, increasing your risk of side effects. Also, combining Pamelor with certain phenothiazines can increase your risk of a dangerous irregular heart rhythm called QT prolongation. Talk to your healthcare provider before taking these medications together.
 
Pressors
Taking Pamelor with pressor medications can increase your risk of side effects. Your healthcare provider may need to adjust your dose of these medications.
 
SSRIs or SNRIs
Taking Pamelor with SSRIs or SNRIs can increase the level of Pamelor in your blood, increasing your chance of side effects and increasing the risk for serotonin syndrome. Your healthcare provider may need to adjust your dose of these medications or use caution when switching from one medicine to another.
 
St. John's Wort
Combining Pamelor with St. John's wort may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Thyroid Medications
Taking Pamelor with thyroid medications can increase your risk of Pamelor side effects. Your healthcare provider may need to adjust your dose of these medications.
 
Tramadol
Combining Pamelor with tramadol may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. 
 
Tricyclic Antidepressants
Taking Pamelor with other tricyclic antidepressants can increase your risk of side effects. Your healthcare provider may need to adjust your dose of these medications.
 
Triptans
Combining Pamelor with a triptan may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
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