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Pamelor Drug Interactions

Pamelor interactions with other medications, such as anticholinergic medications, arrhythmia medications, or MAOIs, can cause the body to metabolize the medications differently than intended. Some of these drug interactions with Pamelor can increase the amounts of certain medications in the blood, increasing your risk of side effects or increasing your risk of a dangerous arrhythmia called QT prolongation. Your healthcare provider may need to adjust your dosage of these medications.

Pamelor Drug Interactions: An Introduction

 Pamelor® (nortriptyline hydrochloride) can potentially interact with many medicines. Some of the medicines that may lead to Pamelor interactions include:
 
  • Alcohol
     
  • Anticholinergic medications, including:

 

 

  • Arrhythmia medications, including:

 

    • Amiodarone (Cordarone®)
    • Disopyramide (Norpace®)
    • Dofetilide (Tikosyn®)
    • Flecainide (Tambocor®)
    • Ibutilide (Corvert®)
    • Propafenone (Rythmol®)
    • Quinidine
    • Sotalol (Betapace®) 

 

  • Barbiturates, including:

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®) 

 

  • Chlorpropamide (Diabinese®)
     
  • Cimetidine (Tagamet®)
     
  • Monoamine oxidase inhibitors (MAOIs), including:

 

 

  • Phenothiazine medications, including:

 

 

  • Pressors, including:

 

    • Dopamine (Intropin®)
    • Dobutamine (Dobutrex®)
    • Epinephrine (Adrenalin®, EpiPen®)
    • Norepinephrine (Levophed®) 

 

 

 
  • Thyroid medications, including:

 

 

 

 


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(Pamelor Drug Interactions Continued: Page 2)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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