Medications
 
 

Drug Interactions With Paroxetine

Paroxetine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when paroxetine is combined with any of the drugs listed above.
 
Alcohol
Combining alcohol and paroxetine may cause unwanted side effects (see Alcohol and Paxil).
 
Aspirin
Taking paroxetine and aspirin together can increase your risk of stomach bleeding. Talk to your healthcare provider before taking aspirin and paroxetine together.
 
Atomoxetine (Strattera)
Paroxetine can increase the level of Strattera in your blood, increasing your risk of side effects. If you are taking paroxetine with Strattera, your healthcare provider may need to lower your Strattera dosage.
 
Certain Arrhythmia Medications
Taking paroxetine with certain arrhythmia medications can increase the level of paroxetine or the arrhythmia medication in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor you more closely and may need to adjust your dose of these medications.
 
Certain Seizure Medications
Certain seizure medications (phenobarbital and phenytoin) may decrease the level of paroxetine in your blood, perhaps making it less effective. Also, taking these medications with paroxetine can lead to increased drowsiness. Your healthcare provider may need to adjust your dose of these medications.
 
Cimetidine (Tagamet)
Taking cimetidine with paroxetine can increase the level of paroxetine in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your paroxetine dose or may suggest an alternative to cimetidine.
Drug Interactions With Paroxetine Article Continues on Next Page >

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
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