Drug Interactions With Paroxetine

Linezolid (Zyvox)
Taking paroxetine with linezolid can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of the symptoms mentioned above, as serotonin syndrome can be very dangerous.
 
Lithium (Eskalith, Lithobid)
Taking paroxetine with lithium can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see "Linezolid"), as it can be very dangerous.
 
Miscellaneous Antidepressants
Combining paroxetine with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors (MAOIs)
Taking paroxetine and an MAOI together can cause life-threatening side effects. Never take an MAOI and paroxetine at the same time, and do not take them within two weeks of each other (for most MAOIs).
 
If a person taking paroxetine needs to be on linezolid or methylene blue and there are no acceptable alternatives, then paroxetine should be stopped right away. The individual should be very closely monitored. Paroxetine may be resumed 24 hours after the last dose of linezolid or methylene blue.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Taking paroxetine and a NSAID together can increase your risk of stomach bleeding. Talk to your healthcare provider before taking NSAIDs and paroxetine together.
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