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Drug Interactions With Paroxetine

Paroxetine can interact with a number of drugs, including warfarin, lithium, and nonsteroidal anti-inflammatory drugs (such as ibuprofen). Some of these drug interactions with paroxetine can lead to problems such as stomach bleeding, increased drowsiness, or a very dangerous combination of symptoms called serotonin syndrome.

 

Drug Interactions With Paroxetine: An Introduction

 Paroxetine hydrochloride (Paxil®) can potentially interact with a number of drugs. Some of the drugs that can lead to paroxetine interactions include:
 
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
o Ibuprofen (Motrin®, Advil®)
o Diclofenac (Cataflam®, Voltaren®)
o Ketoprofen (Orudis®)
  • Phenothiazine medications, including:
o Promethazine (Phenergan®)
  • Tryptophan
  • Warfarin (Coumadin®, Jantoven®).
     
(Drug Interactions With Paroxetine Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;