Side Effects of Paroxetine

Some of the most common paroxetine side effects include ejaculation problems, nausea, and drowsiness. A few examples of side effects rarely seen with the drug include muscle spasms, heartburn, and abnormal dreams. Notify your healthcare provider immediately if you experience serious side effects such as a fast heart rate, or suicidal thoughts.

This article refers to the original, immediate-release paroxetine products (Paxil). Paroxetine is also the active ingredient in a few other products. For information about these other paroxetine products, please see:

Paroxetine Side Effects: An Introduction

As with any medicine, there are possible side effects with paroxetine hydrochloride (Paxil®). However, not everyone who takes paroxetine will experience side effects. In fact, most people tolerate it well. When side effects do occur, in most cases they are minor and either require no treatment or can be easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with paroxetine. Your healthcare provider can discuss a more complete list of paroxetine side effects with you.)

Side Effects of Paroxetine to Report

There are a number of side effects of paroxetine that you should report to your healthcare provider, including, but not limited to:
  • Suicidal thoughts or behavior (see Paxil and Suicide)
  • Anxiety, agitation, or panic attacks
  • Hostility or aggressiveness
  • Engaging in unusual or dangerous activities
  • Extreme elation or feeling of happiness that may switch back and forth with a depressed or sad mood
  • Other unusual changes in behavior
  • Signs of serotonin syndrome (a rare but dangerous problem associated with certain medications), such as:
    • Confusion or other mental changes
    • A rapid heart rate
    • Nausea, vomiting, or diarrhea
    • Hallucinations
    • Blood pressure changes
    • An irregular heart rhythm
    • Overactive reflexes
    • Fever, sweating, or shivering
    • Shakiness
    • Agitation
    • Seizures
    • Coma


  • Chest palpitations
  • Easily broken bones 
  • Difficulty sleeping
  • Feelings of internal restlessness or jitteriness
  • Signs of an allergic reaction, including unexplained rash, hives, itching, unexplained swelling, wheezing, or difficulty breathing or swallowing.
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Paroxetine HCl

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