Paxil CR Drug Interactions

Paxil CR and Serotonin Syndrome

Several of the known interactions with Paxil CR are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.

Paxil CR Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Paxil CR is combined with any of the drugs listed above.
It is not recommended that you drink alcohol while taking Paxil CR. Combining alcohol and Paxil CR may cause unwanted side effects (see Alcohol and Paxil CR).
Taking Paxil CR and aspirin together can increase your risk of stomach bleeding. Talk with your healthcare provider before taking aspirin and Paxil CR together.
Atomoxetine (Strattera)
Paxil CR can raise the level of Strattera in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to lower your Strattera dosage.
Buspirone (BuSpar)
Because combining Paxil CR with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
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