Paxil CR Drug Interactions

Certain Arrhythmia Medications
Taking Paxil CR with certain arrhythmia medications can raise the level of Paxil CR or the arrhythmia medication in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to monitor you more closely and may need to adjust your doses of these medications.
 
Certain Seizure Medications
Certain seizure medications (phenobarbital and phenytoin) may decrease the level of Paxil CR in your blood, perhaps making it less effective. Also, taking these two medications together can lead to increased drowsiness. If you are taking these drugs together, your healthcare provider may need to adjust your doses of them.
 
Cimetidine (Tagamet)
Taking cimetidine with Paxil CR can raise the level of Paxil CR in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to lower your Paxil CR dose or suggest an alternative to cimetidine.
 
Digoxin (Digitek, Lanoxin)
Taking Paxil CR and digoxin together may decrease the level of digoxin in your blood. Your healthcare provider may need to adjust your digoxin dose when you are starting or stopping Paxil CR.
 
Fentanyl
Combining Paxil CR with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Intravenous Methylene Blue
Taking Paxil CR with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Linezolid (Zyvox)
Taking Paxil CR with linezolid can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of the symptoms mentioned above, as serotonin syndrome can be very dangerous.
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Information on Paxil CR

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