Paxil CR Drug Interactions

Lithium (Eskalith, Lithobid)
Taking Paxil CR with lithium can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Miscellaneous Antidepressants
Combining Paxil CR with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors (MAOIs)
Taking Paxil CR and an MAOI together can cause life-threatening side effects. Never take an MAOI and Paxil CR at the same time, and do not take Paxil CR if you have taken an MAOI within the past 14 days (for most MAOIs). Also, because Paxil CR stays in your system for so long, do not take an MAOI if you have taken Paxil CR within the past five weeks (for most MAOIs).
 
If a person taking Paxil CR needs to be on linezolid or methylene blue and there are no acceptable alternatives, then Paxil CR should be stopped right away. The individual should be very closely monitored. Paxil CR may be resumed 24 hours after the last dose of linezolid or methylene blue.
 
Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Taking Paxil CR and NSAIDs together can increase your risk of stomach bleeding. Talk with your healthcare provider before taking NSAIDs and Paxil CR together.
 
Phenothiazines
Paxil CR can raise the levels of phenothiazine medications in your blood, increasing your risk of side effects. Also, taking these medications can increase your chance of drowsiness. Talk with your healthcare provider before taking these medications together.
 
One particular phenothiazine, thioridazine (Mellaril), should generally not be taken in combination with Paxil CR, due to the risk of a dangerous irregular heart rhythm (arrhythmia) called QT prolongation.
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Information on Paxil CR

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