Pexeva Drug Interactions

Atomoxetine
Pexeva can increase the levels of atomoxetine in your body, increasing your risk for side effects. If you take these medications together, you may need a lower dose of atomoxetine.
 
Beta Blockers
Pexeva may increase the levels of certain (but not all) beta blockers in your body. This may lead to low blood pressure (hypotension). If you take Pexeva with a beta blocker, your healthcare provider may choose to monitor your blood pressure and pulse closely, and lower your beta blocker dose if needed.
 
Buspirone (BuSpar)
Because combining Pexeva with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
 
Cimetidine
Taking cimetidine with Pexeva can increase the level of Pexeva in your blood, increasing your risk for side effects. Your healthcare provider may need to lower your Pexeva dosage or may suggest an alternative to cimetidine.
 
CYP 2D6 Inhibitor Medications
The body breaks down Pexeva using enzymes in the liver known as CYP 2D6 enzymes. Medications known as CYP 2D6 inhibitors can decrease the activity of these enzymes. Combining Pexeva with one of these CYP 3A4 inhibitors may increase the level of Pexeva in your body, increasing your risk for side effects. Your healthcare provider may monitor you more closely in this case, and may need to decrease your Pexeva dose if you take it with a CYP 2D6 inhibitor.
 
Cyproheptadine
Cyproheptadine may make Pexeva less effective at treating depression. If you take these medications together, your healthcare provider may choose to closely monitor your depression symptoms to make sure Pexeva is working for you.
 
Fentanyl
Combining Pexeva with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Galantamine
Pexeva may increase the amount of galantamine in your body, increasing your risk for side effects. If you take these medications together, your healthcare provider may need to monitor you for side effects of galantamine. You may need a lower galantamine dosage.
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Pexeva Medication Information

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