Pexeva Warnings and Precautions

Specific Precautions and Warnings for Pexeva

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • Just like other antidepressants, Pexeva may increase the risk of suicidal thinking or behavior in children, adolescents, and young adults. Anyone taking an antidepressant should be closely monitored for worsening depression, suicidal thoughts, and any unusual behavior, especially in the beginning of treatment and whenever the dose is increased (see Pexeva and Suicide for more information).
  • Before prescribing Pexeva for depression, your healthcare provider should make sure that you do not have bipolar disorder instead. Bipolar disorder involves alternating cycles of depression and mania (an overly excited or elevated mood). There is a concern that antidepressants like Pexeva may lead to mania in people with bipolar disorder.
  • Antidepressants like Pexeva can cause a dangerous reaction known as serotonin syndrome. Taking Pexeva with other medications that affect serotonin levels can increase your risk for this reaction; however, it may also occur with Pexeva alone. Contact your healthcare provider immediately if you notice any possible symptoms of this condition, including:
    • Confusion
    • Seeing or hearing things that are not really there (hallucinations)
    • Fast heartbeat (tachycardia)
    • Fever
    • Sweating
    • Nausea and vomiting
    • Diarrhea
    • Muscle spasms
    • Difficulty walking.
  • In rare cases, this medication may increase the risk for seizures, especially in people with a seizure disorder. Talk to your healthcare provider before taking Pexeva if you have a seizure disorder, or have ever had a seizure.
  • Pexeva may cause a condition known as akathisia, which is an internal feeling of restlessness, especially at the start of treatment. People with this condition find it difficult to sit or stand still. Talk to your healthcare provider if you experience these symptoms while taking Pexeva.
  • This medicine may cause low blood sodium (hyponatremia). Older adults, people taking diuretics ("water pills"), and people who are dehydrated appear to have a greater risk for hyponatremia with Pexeva use. If you develop symptoms of hyponatremia, contact your healthcare provider. Early symptoms may include:
    • Headache
    • Confusion
    • Problems concentrating
    • Memory problems
    • Weakness
    • Unsteadiness or falling down.
  • In general, this medication should not be stopped abruptly, as doing so may lead to withdrawal symptoms. If you need to stop taking it, your healthcare provider will slowly take you off this medication. If you do develop any symptoms of Pexeva withdrawal, such as headache, irritability, anxiety, confusion, or insomnia, your healthcare provider may take you off it even slower.
  • Pexeva may cause bleeding in the stomach or intestines. This risk is increased in those taking aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen. Symptoms of gastrointestinal bleeding may include:
    • Bright-red blood coating the stool
    • Dark blood mixed with the stool
    • Black or tarry stool
    • Bright-red blood in vomit
    • Vomit that has the appearance of coffee grounds.
If you experience any of these symptoms, call your healthcare provider right away.
  • If you have severe liver problems or kidney problems, you may need a lower Pexeva dosage. Make sure your healthcare provider knows if you have liver or kidney problems before starting treatment.
  • Pexeva may make glaucoma (a condition of the eye) worse. Talk to your healthcare provider before taking this drug if you have glaucoma.
  • This medicine may affect your ability to perform complex tasks requiring mental and motor skills. Taking Pexeva with alcohol or other medications that cause drowsiness can increase this effect. To be safe, do not perform activities requiring mental or motor concentration (such as driving a car or operating machinery) until you know how this medication affects you.
  • Pexeva is considered a pregnancy Category D medication. This means that the drug may cause harm to an unborn baby if it is used during pregnancy (see Pexeva and Pregnancy for more information).
  • This medicine passes through breast milk. Therefore, if you are breastfeeding or plan to start, be sure to talk with your healthcare provider before taking it (see Pexeva and Breastfeeding).
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Pexeva Medication Information

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