Medications
 
 

Pristiq Drug Interactions

Pristiq Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Pristiq is combined with any of the drugs listed above.
 
Alcohol
People are typically advised to avoid alcohol while taking Pristiq. Consuming alcohol and Pristiq together may cause unwanted side effects.
 
Anticoagulant or Antiplatelet Medications
Combining Pristiq with medications that "thin" the blood (medications with anticoagulant or antiplatelet properties) could increase the risk of bleeding. Check with your healthcare provider before taking Pristiq with any of these medications.
 
Ketoconazole (Nizoral)
Taking Pristiq with ketoconazole may increase the level of Pristiq in your blood, possibly increasing your risk of side effects. Your healthcare provider may need to decrease your Pristiq dosage to prevent this from occurring.
 
Linezolid (Zyvox)
Taking Pristiq with a linezolid can cause a group of symptoms called serotonin syndrome. These symptoms include:
 
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
 
Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
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