Pristiq Drug Interactions

Fentanyl
Combining Pristiq with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Intravenous Methylene Blue
Taking Pristiq with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Linezolid (Zyvox)
Taking Pristiq with a linezolid can cause a group of symptoms called serotonin syndrome. These symptoms include:
 
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
 
Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.
 
Lithium (Eskalith, Lithobid)
Taking Pristiq with lithium can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
Miscellaneous Antidepressants
Combining Pristiq with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors (MAOIs)
Taking Pristiq with an MAOI can cause life-threatening side effects. Do not take Pristiq if you have taken an MAOI within the past two weeks. Also, do not take an MAOI if you have taken Pristiq within the past seven days.
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Pristiq Drug Information

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