Sexual Side Effects of Pristiq

Ejaculation problems, decreased sex drive, and orgasm problems are some of the sexual side effects that may occur with Pristiq. Fortunately, there are many options your healthcare provider can recommend if you develop any of these problems. For example, he or she could adjust your dosage, switch you to another medication, or add another medication that could help reduce these sexual side effects.

Does Pristiq Cause Sexual Side Effects?

Pristiq® (desvenlafaxine succinate) is a prescription antidepressant, and like many other antidepressants, Pristiq can cause certain sexual side effects. These may include:
  • Orgasm problems
  • Decreased sex drive
  • Ejaculation problems
  • "Sexual dysfunction."
Orgasm Problems
In clinical studies, up to 8 percent of men and up to 3 percent of women experienced an inability to achieve orgasm (a problem known medically as anorgasmia). Up to 3 percent of men experienced an "abnormal" orgasm.
Problems With Sex Drive
Pristiq is also known to cause a decrease in sex drive (known as libido). In clinical studies, a decreased sex drive occurred in up to 6 percent of men. This problem was not reported in women.
Ejaculation Problems
Pristiq may sometimes cause ejaculation problems. In clinical studies, up to 7 percent of men taking the drug reported experiencing a delay in ejaculation, while up to 2 percent reported complete failure in ejaculation. "Ejaculation dysfunction" was reported in up to 11 percent of men, and "ejaculation disorder" was reported in up to 5 percent of men.
It is unclear what exactly is meant by these last two terms, but they probably involve retrograde ejaculation, a condition wherein ejaculate enters the bladder instead of going out through the penis. Retrograde ejaculation is not a cause for medical concern, unless a man and his partner are trying to conceive a child.
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