Drug Interactions With Protriptyline

Protriptyline Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when protriptyline is combined with any of the drugs listed above.
 
Alcohol
Protriptyline may enhance the effects of alcohol. This can lead to an increased risk of suicidal thoughts and other overdose symptoms. Make sure to talk with your healthcare provider about drinking alcohol while taking the drug.
 
Anticholinergic Medications
Taking protriptyline with anticholinergic medications may cause increased side effects. Talk to your healthcare provider before using these medications together, as your dosages may need to be reduced. Since anticholinergic medications are found in some over-the-counter medicines, do not treat yourself for the common cold, a cough, or allergies without first talking to your healthcare provider.
 
Arrhythmia Medications
Combining protriptyline with arrhythmia medications can increase your risk of a dangerous arrhythmia called QT prolongation. Also, certain arrhythmia medications can increase the level of protriptyline in your blood, increasing your risk of side effects. Talk to your healthcare provider before taking these medications together.
 
Cimetidine
If protriptyline is taken with cimetidine, this can increase the level of protriptyline in your blood, increasing your chance of side effects. Your healthcare provider may need to adjust your dose of these medications to prevent this interaction from occurring.
 
Cisapride
Taking cisapride with protriptyline can increase your risk of a dangerous irregular heart rhythm called QT prolongation. Do not take these two medications together.
 
Monoamine Oxidase Inhibitors
Taking protriptyline with MAOIs can increase your chance of developing dangerous side effects. Do not take protriptyline if you have taken an MAOI within the past two weeks.
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