Protriptyline Side Effects

Changes in blood sugar levels, weight gain, and dry mouth are some of adverse side effects that have been reported with protriptyline. Side effects are typically mild and easily treated, but certain problems may be more serious and should be reported to a healthcare provider immediately. Contact your healthcare provider right away if you develop serious protriptyline side effects, such as jaundice, hallucinations, or difficulty sleeping.

Protriptyline Side Effects: An Introduction

As with any medicine, side effects are possible with protriptyline hydrochloride (Vivactil®). However, not everyone who takes the medication will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in many cases, they are minor, meaning they require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with protriptyline. Your healthcare provider can discuss a more complete list of protriptyline side effects with you.)

Reported Protriptyline Side Effects

Protriptyline has been studied thoroughly in clinical trials, in which a group of people taking the drug have side effects documented and compared to another group not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
In these studies, some of the side effects of protriptyline included:
Protriptyline seems less likely to cause drowsiness than other tricyclic antidepressants.
Withdrawal side effects have been reported in people who have stopped taking the drug suddenly. These side effects include:
  • Nausea
  • Headache
  • A general ill feeling.


(Click Vivactil Withdrawal for more information.)
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Protriptyline (Vivactil)

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